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Article

MESD is essential for apical localization of megalin/LRP2 in the visceral endoderm.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Mar 2011

Lighthouse Janet K, Zhang Liqun, Hsieh Jen-Chih, Rosenquist Thomas, Holdener Bernadette C

Abstract excerpt

Deletion of the Mesd gene region blocks gastrulation and mesoderm differentiation in mice. MESD is a chaperone for the Wnt co-receptors: low-density lipoprotein receptor-related protein (LRP) 5 and 6 (LRP5/6). We hypothesized that loss of Wnt signaling is responsible for the polarity defects observed in Mesd-deficient embryos. However, because the Mesd-deficient embryo is considerably smaller than Lrp5/6 or Wnt3...

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Source

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Identifiers

PMID: 21337463
DOI: 10.1002/dvdy.22477
PMCID: PMC3069535

Genes

MESD
LRP2
EGF
LRP5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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