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Article

The structure of MESD45-184 brings light into the mechanism of LDLR family folding.

Structure (London, England : 1993) - 9 Mar 2011

Köhler Christian, Lighthouse Janet K, Werther Tobias, Andersen Olav M, Diehl Annette, Schmieder Peter, Du Jianguang, Holdener Bernadette C, Oschkinat Hartmut

Abstract excerpt

Mesoderm development (MESD) is a 224 amino acid mouse protein that acts as a molecular chaperone for the low-density lipoprotein receptor (LDLR) family. Here, we provide evidence that the region 45-184 of MESD is essential and sufficient for this function and suggest a model for its mode of action. NMR studies reveal a β-α-β-β-α-β core domain with an α-helical N-terminal extension that interacts with the β sheet...

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Source

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Identifiers

PMID: 21397185
DOI: 10.1016/j.str.2010.12.022
PMCID: PMC5841080

Genes

MESD
LDLR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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