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Article

Ankrd6 is a mammalian functional homolog of Drosophila planar cell polarity gene diego and regulates coordinated cellular orientation in the mouse inner ear.

Developmental biology - 1 Nov 2014

Jones Chonnettia, Qian Dong, Kim Sun Myoung, Li Shuangding, Ren Dongdong, Knapp Lindsey, Sprinzak David, Avraham Karen B, Matsuzaki Fumio, Chi Fanglu, Chen Ping

Abstract excerpt

The coordinated polarization of neighboring cells within the plane of the tissue, known as planar cell polarity (PCP), is a recurring theme in biology. It is required for numerous developmental processes for the form and function of many tissues and organs across species. The genetic pathway regulating PCP was first discovered in Drosophila, and an analogous but distinct pathway is emerging in vertebrates. It...

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Identifiers

PMID: 25218921
DOI: 10.1016/j.ydbio.2014.08.029
PMCID: PMC4837453

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