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Article

Interaction of ibuprofen and probenecid with drug metabolizing enzyme phenotyping procedures using caffeine as the probe drug.

British journal of clinical pharmacology - 1 Feb 2003

Vrtic Fatima, Haefeli Walter E, Drewe Jürgen, Krähenbühl Stephan, Wenk Markus

Abstract excerpt

AIMS: To examine the suspected inhibitory potential of the over-the-counter (OTC) drug ibuprofen on N-acetyltransferase 2 (NAT2) in vitro and in vivo and the possible implications for phenotyping procedures using caffeine as probe drug. METHODS: We first studied the inhibitory effect of ibuprofen on NAT2 in vitro, using human liver cytosol and sulfamethazine as substrate. In vivo 15 fast and 15 slow acetylating...

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Share to Arylamine N-Acetyltransferase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP1A2

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Source

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Identifiers

PMID: 12580991
DOI: 10.1046/j.1365-2125.2003.01725.x
PMCID: PMC1894741

Genes

NAT2
OAT
OTC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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