Article
Determination of N-acetylation phenotyping in a Greek population using caffeine as a metabolic probe.
European journal of drug metabolism and pharmacokinetics - 1 Jan 2000
Asprodini E K, Zifa E, Papageorgiou I, Benakis A
Abstract excerpt
Studies of isoniazid, the well known antituberculosis drug, have revealed that N-acetylation polymorphism, is of great clinical importance. In humans, N-acetylation is one of the most important pathways in the inactivation of isoniazid. Caffeine, which is also biotransformed by N-acetylation, has been widely used as an in vivo probe for the assessment of N-acetyltransferase polymorphism. The activity of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.