Article
Phenotyping of N-acetyltransferase type 2 and xanthine oxidase with caffeine: when should urine samples be collected?
European journal of clinical pharmacology - 1 Apr 2009
Jetter Alexander, Kinzig Martina, Rodamer Michael, Tomalik-Scharte Dorota, Sörgel Fritz, Fuhr Uwe
Abstract excerpt
OBJECTIVES: Individual activities of N-acetyltransferase 2 (NAT2) and of xanthine oxidase (XO) can be assessed using ratios of urinary caffeine metabolites. We investigated how ratios changed over time and which urine collection interval would be the best for NAT2 and XO activity assessments. METHODS: On two occasions separated by 14 days, 16 healthy male Caucasians collected urine before and 0-2, 2-4, 4-6, 6-8,...
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