Caffeine as a metabolic probe: validation of its use for acetylator phenotyping.

doi:10.1038/clpt.1991.82

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Article

Caffeine as a metabolic probe: validation of its use for acetylator phenotyping.

Clinical pharmacology and therapeutics - 1 Jun 1991

Tang B K, Kadar D, Qian L, Iriah J, Yip J, Kalow W

Abstract excerpt

The use of two caffeine metabolite ratios for acetylator phenotyping was validated by demonstrating concordance with two sulfamethazine tests in 178 unrelated healthy subjects. The caffeine metabolites used for this purpose were 5-acetylamino-6-amino-3-methyluracil (AAMU), 1-methylxanthine (1X),...

Topics

Acetylation
Acetyltransferases
Adult
Caffeine
Humans
Phenotype
Polymorphism, Genetic
Sulfamethazine
Time Factors
Uracil
Uric Acid
Xanthines

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