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Article

Caffeine as a metabolic probe: NAT2 phenotyping.

British journal of clinical pharmacology - 1 Mar 1996

Notarianni L J, Dobrocky P, Godlewski G, Jones R W, Bennett P N

Abstract excerpt

1. Caffeine has been used to determine acetylator phenotype for some 15 years but the interpretation of metabolic ratios with this substance raises theoretical and methodological issues. 2. N-acetyltransferase type 2 (NAT2) status was assessed in 23 young healthy subjects using both caffeine overnight and spot urine samples, and sulphadimidine. 3. Frequency distribution analysis of the metabolic ratios of NAT2,...

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Source

Identifiers

PMID: 8866914
DOI: 10.1111/j.1365-2125.1996.tb00178.x

Genes

NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Caffeine as a metabolic probe: NAT2 phenotyping.PMID 8866914Read ↗

Caffeine as a metabolic probe: validation of its use for acetylator phenotyping.Semantic proximity Read ↗

Phenotyping of N-acetyltransferase type 2 by caffeine from uncontrolled dietary exposure.Semantic proximity Read ↗

The effect of NAT2 genotype and gender on the metabolism of caffeine in nonsmoking subjects.Semantic proximity Read ↗

Determination of CYP1A2 and NAT2 phenotypes in human populations by analysis of caffeine urinary metabolites.Semantic proximity Read ↗

Acetylator phenotyping: the urinary caffeine metabolite ratio in slow acetylators correlates with a marker of systemic NAT1 activity.Semantic proximity Read ↗

Mesalazine pharmacokinetics and NAT2 phenotype.Semantic proximity Read ↗

Phenotyping of N-acetyltransferase type 2 and xanthine oxidase with caffeine: when should urine samples be collected?Semantic proximity Read ↗

NAT2 and CYP1A2 phenotyping with caffeine: head-to-head comparison of AFMU vs. AAMU in the urine metabolite ratios.Semantic proximity Read ↗

Validity of an ELISA for N-acetyltransferase-2 (NAT2) phenotyping.Semantic proximity Read ↗

Caffeine metabolic ratios for the in vivo evaluation of CYP1A2, N-acetyltransferase 2, xanthine oxidase and CYP2A6 enzymatic activities.Semantic proximity Read ↗

N-Acetyltransferase-2 (NAT2) gene polymorphisms and enzyme activity in Serbs: unprecedented high prevalence of rapid acetylators in a White population.Semantic proximity Read ↗

Discordance between N-acetyltransferase 2 phenotype and genotype in a population of Hmong subjects.Semantic proximity Read ↗

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