Validity of an ELISA for N-acetyltransferase-2 (NAT2) phenotyping.

doi:10.1016/s0022-1759(01)00310-6

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Article

Validity of an ELISA for N-acetyltransferase-2 (NAT2) phenotyping.

Journal of immunological methods - 1 May 2001

Wong P, Banerjee K, Massengill J, Nowell S, Lang N, Leyland-Jones B

Abstract excerpt

A competitive antigen ELISA was previously developed for NAT2 phenotyping, using caffeine as the probe drug. The ELISA phenotypes by measuring the ratio of 5-acetamido-6-amino-3-methyluracil (AAMU) and 1-methylxanthine (1X) after transformation of 5-acetamido-6-formylamino-3-methyluracil (AFMU) to AAMU, in contrast to capillary electrophoresis high-pressure liquid chromatography (HPLC) which phenotype by...

Topics

Arylamine N-Acetyltransferase
Caffeine
Chromatography, High Pressure Liquid
Enzyme-Linked Immunosorbent Assay
Genotype
Humans
Phenotype
Uracil
Xanthines

Source

Open in PubMed

Identifiers

PMID: 11292476
DOI: 10.1016/s0022-1759(01)00310-6

Genes

NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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