Article
Heterotrimeric G proteins direct two modes of asymmetric cell division in the Drosophila nervous system.
Cell - 19 Oct 2001
Schaefer M, Petronczki M, Dorner D, Forte M, Knoblich J A
Abstract excerpt
In Drosophila, distinct mechanisms orient asymmetric cell division along the apical-basal axis in neuroblasts and along the anterior-posterior axis in sensory organ precursor (SOP) cells. Here, we show that heterotrimeric G proteins are essential for asymmetric cell division in both cell types. The G protein subunit G(alpha)i localizes apically in neuroblasts and anteriorly in SOP cells before and during mitosis....
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