Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Attenuation of a phosphorylation-dependent activator by an HDAC-PP1 complex.

Nature structural biology - 1 Mar 2003

Canettieri Gianluca, Morantte Ianessa, Guzmán Ernesto, Asahara Hiroshi, Herzig Stephan, Anderson Scott D, Yates John R, Montminy Marc

Abstract excerpt

The second messenger cAMP stimulates transcription with burst-attenuation kinetics that mirror the PKA-dependent phosphorylation and subsequent protein phosphatase 1 (PP1)-mediated dephosphorylation of the cAMP responsive element binding protein (CREB) at Ser133. Phosphorylation of Ser133 promotes recruitment of the co-activator histone acetylase (HAT) paralogs CBP and P300, which in turn stimulate acetylation of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Colforsin
Share to Cyclic AMP

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cyclic AMP Response Element-Binding Protein

Share to Histone Deacetylase 1

Share to Histone Deacetylases

Share to Macromolecular Substances

Share to Phosphoprotein Phosphatases

Share to Protein Phosphatase 1

Source

Identifiers

PMID: 12567184
DOI: 10.1038/nsb895

Genes

HDAC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Attenuation of a phosphorylation-dependent activator by an HDAC-PP1 complex.PMID 12567184Read ↗

Histone acetylation by p300 is involved in CREB-mediated transcription on chromatin.Semantic proximity Read ↗

PP‐1β and PP‐2Aα modulate cAMP response element‐binding protein (CREB) functions in aging control and stress response through de‐regulation of αB‐crystallin gene and p300‐p53 signaling axisSemantic proximity Read ↗

Combinatorial regulation of a signal-dependent activator by phosphorylation and acetylation.Semantic proximity Read ↗

CREB phosphorylation at Ser133 regulates transcription via distinct mechanisms downstream of cAMP and MAPK signalling.Semantic proximity Read ↗

CREB in the Pathophysiology of Cancer: Implications for Targeting Transcription Factors for Cancer TherapySemantic proximity Read ↗

The Pleiotropic Face of CREB Family Transcription FactorsSemantic proximity Read ↗

Protein-kinase-A-dependent activator in transcription factor CREB reveals new role for CREM repressors.Semantic proximity Read ↗

Characterization of a CREB gain-of-function mutant with constitutive transcriptional activity in vivo.Semantic proximity Read ↗

Polycomb inhibits histone acetylation by CBP by binding directly to its catalytic domain.Semantic proximity Read ↗

Is histone acetylation the most important physiological function for CBP and p300?Semantic proximity Read ↗

Role of the PKA‐Regulated Transcription Factor CREB in Development and Tumorigenesis of Endocrine TissuesSemantic proximity Read ↗

The cAMP signalling pathway activates CREB through PKA, p38 and MSK1 in NIH 3T3 cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.