CREB in the Pathophysiology of Cancer: Implications for Targeting Transcription Factors for Cancer Therapy

Abstract excerpt

Transcription factors are key regulators of the pattern of gene expression in a cell and directly control central processes such as proliferation, survival, self-renewal, and invasion. Given this critical role, the function of transcription factors is normally regulated closely, often through transient phosphorylation. Although transcription factors are not often directly modified by mutations in cancer cells,...

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