Article
Combinatorial regulation of a signal-dependent activator by phosphorylation and acetylation.
Proceedings of the National Academy of Sciences of the United States of America - 2 Dec 2014
Paz Jose C, Park Sangho, Phillips Naomi, Matsumura Shigenobu, Tsai Wen-Wei, Kasper Lawryn, Brindle Paul K, Zhang Guangtao, Zhou Ming-Ming, Wright Peter E, Montminy Marc
Abstract excerpt
In the fasted state, increases in catecholamine signaling promote adipocyte function via the protein kinase A-mediated phosphorylation of cyclic AMP response element binding protein (CREB). CREB activity is further up-regulated in obesity, despite reductions in catecholamine signaling, where it contributes to the development of insulin resistance. Here we show that obesity promotes the CREB binding protein...
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