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Article

Testicular cancer susceptibility in the 129.MOLF-Chr19 mouse strain: additive effects, gene interactions and epigenetic modifications.

Human molecular genetics - 15 Feb 2003

Youngren Kirsten K, Nadeau Joseph H, Matin Angabin

Abstract excerpt

Testicular germ cell tumors (TGCTs) are the most common solid cancers affecting young men. Although the evidence for genetic predisposition to TGCTs in humans is compelling, the genetic control of susceptibility is poorly understood. The 129S1/SvImJ (129/Sv) inbred strain of mice is an excellent model for studying TGCT susceptibility. We previously reported a new mouse strain, the 129.MOLF-Chr19 chromosome...

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Identifiers

PMID: 12566386
DOI: 10.1093/hmg/ddg036

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