Article
High-resolution genetic map of X-linked juvenile-type granulosa cell tumor susceptibility genes in mouse.
Cancer research - 1 Dec 2003
Dorward Ann M, Shultz Kathryn L, Ackert-Bicknell Cheryl L, Eicher Eva M, Beamer Wesley G
Abstract excerpt
SWR/Bm (SWR) female mice spontaneously develop early-onset ovarian granulosa cell (GC) tumors that can progress to metastatic carcinoma and thus provide a model system for human, juvenile-type GC tumors. In SWR mice, GC tumor susceptibility is an inherited, polygenic trait that appears at a low frequency. A dramatic increase in tumor frequency occurs when the autosomal SWR genetic complement is combined with the...
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