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Article

Susceptibility to testicular germ-cell tumours in a 129.MOLF-Chr 19 chromosome substitution strain.

Nature genetics - 1 Oct 1999

Matin A, Collin G B, Asada Y, Varnum D, Nadeau J H

Abstract excerpt

The identification of genes that control susceptibility to testicular germ-cell tumours (TGCTs), the most common cancer affecting young men, has been difficult. In laboratory mice, TGCTs arise from primordial germ cells in only the 129 inbred strains, and susceptibility is under multigenic control. The spontaneously arising mutation Ter (ref. 5) on mouse chromosome 18 (Refs 6,7) increases TGCT frequency on a...

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Identifiers

PMID: 10508525
DOI: 10.1038/13874

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Susceptibility to testicular germ-cell tumours in a 129.MOLF-Chr 19 chromosome substitution strain.PMID 10508525Read ↗

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Testicular germ cell tumor susceptibility genes from the consomic 129.MOLF-Chr19 mouse strain.Semantic proximity Read ↗

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Enhancers and suppressors of testicular cancer susceptibility in single- and double-mutant mice.Semantic proximity Read ↗

Phenotype and gene signature of testicular tumors in 129.MOLF-Chr19 mice resemble human teratomas.Semantic proximity Read ↗

Genetic control of susceptibility to spontaneous testicular germ cell tumors in mice.Semantic proximity Read ↗

Identification of genomic locus responsible for experimentally induced testicular teratoma 1 (ett1) on mouse Chr 18.Semantic proximity Read ↗

A mutation in the Ter gene causing increased susceptibility to testicular teratomas maps to mouse chromosome 18.Semantic proximity Read ↗

A male germ cell tumor-susceptibility-determining locus, pgct1, identified on murine chromosome 13.Semantic proximity Read ↗

Testicular germ cell tumors in mice: new ways to study a genetically complex trait.Semantic proximity Read ↗

Search for testicular cancer gene hits dead-end.Semantic proximity Read ↗

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