Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A male germ cell tumor-susceptibility-determining locus, pgct1, identified on murine chromosome 13.

Proceedings of the National Academy of Sciences of the United States of America - 18 Jul 2000

Muller A J, Teresky A K, Levine A J

Abstract excerpt

Inbred 129 strain mice are predisposed to developing male germ cell tumors (GCTs) of the testes. The inherent genetic defects that underlie male GCT susceptibility in the 129 mouse strain are unknown. GCT incidence is increased in 129 strain males that lack functional p53 protein, and we have used this finding to facilitate the generation of panels of GCT-bearing intercross and backcross mice for genetic mapping...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosome Mapping
Share to Crosses, Genetic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Germinoma

Share to Incidence

Share to Mice, Inbred C57BL

Share to Spermatozoa

Share to Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 10890890
DOI: 10.1073/pnas.140208197
PMCID: PMC26963

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A male germ cell tumor-susceptibility-determining locus, pgct1, identified on murine chromosome 13.PMID 10890890Read ↗

Testicular cancer susceptibility in the 129.MOLF-Chr19 mouse strain: additive effects, gene interactions and epigenetic modifications.Semantic proximity Read ↗

129/Sv mice--a model system for studying germ cell biology and testicular cancer.Semantic proximity Read ↗

Testicular germ cell tumor susceptibility genes from the consomic 129.MOLF-Chr19 mouse strain.Semantic proximity Read ↗

Tumor loci and their interactions on mouse chromosome 19 that contribute to testicular germ cell tumors.Semantic proximity Read ↗

High-resolution genetic map of X-linked juvenile-type granulosa cell tumor susceptibility genes in mouse.Semantic proximity Read ↗

Testicular germ cell tumors in mice: new ways to study a genetically complex trait.Semantic proximity Read ↗

Enhancers and suppressors of testicular cancer susceptibility in single- and double-mutant mice.Semantic proximity Read ↗

Fine map of the Gct1 spontaneous ovarian granulosa cell tumor locus.Semantic proximity Read ↗

Distal Chr 4 harbors a genetic locus (Gct1) fundamental for spontaneous ovarian granulosa cell tumorigenesis in a mouse model.Semantic proximity Read ↗

Genetic factors on mouse chromosome 18 affecting susceptibility to testicular germ cell tumors and permissiveness to embryonic stem cell derivation.Semantic proximity Read ↗

Susceptibility to testicular germ-cell tumours in a 129.MOLF-Chr 19 chromosome substitution strain.Semantic proximity Read ↗

Genetic control of susceptibility to spontaneous testicular germ cell tumors in mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.