Article
Association of GABA(A) receptors and alcohol dependence and the effects of genetic imprinting.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Feb 2003
Song Jiuzhou, Koller Daniel L, Foroud Tatiana, Carr Kristie, Zhao Jinghua, Rice John, Nurnberger John I, Begleiter Henri, Porjesz Bernice, Smith Tom L, Schuckit Marc A, Edenberg Howard J
Abstract excerpt
GABA receptor genes have been postulated as candidates affecting the risk for alcoholism. The potential association between genes encoding five subunits of the GABA(A) receptors and alcoholism (alcohol dependence) was analyzed in the multiplex alcoholic pedigrees collected by the Collaborative Study on the Genetics of Alcoholism (COGA) using family-based association tests. We found consistent, although weak,...
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