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Article

Novel regulation of cardiac force-frequency relation by CREM (cAMP response element modulator).

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Feb 2003

Isoda Takayoshi, Paolocci Nazareno, Haghighi Kobra, Wang Congrong, Wang Yibin, Georgakopoulos Dimitrios, Servillo Giuseppe, Della Fazia Maria Agnese, Kranias Evangelia G, Depaoli-Roach Anna A, Sassone-Corsi Paolo, Kass David A

Abstract excerpt

The cAMP response element modulator (CREM) plays pivotal roles in the hypothalamic-pituitary-gonadal axis. CREM mRNA is robustly expressed in human myocardium, and identified isoforms may suppress cAMP response element-mediated transcription. However, little is known about the physiological importance of CREM in intact hearts remains unknown. We studied CREM-null mice and age-matched control littermates by in...

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PMID: 12554693
DOI: 10.1096/fj.01-0981com

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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