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Article

In cardiac myocytes, cAMP elevation triggers the down-regulation of transcripts and promoter activity for cyclic AMP phosphodiesterase-4A10 (PDE4A10).

Cellular signalling - 1 Nov 2008

McCahill Angela, Campbell Lachlan, McSorley Theresa, Sood Arvind, Lynch Martin J, Li Xiang, Yan Chen, Baillie George S, Houslay Miles D

Abstract excerpt

Transcripts for the PDE4A10 cyclic AMP phosphodiesterase isoform are present in a wide variety of rat tissues including the heart. Sequence comparisons between the putative human and mouse promoters revealed a number of conserved regions including both an Sp1 and a CREB-binding site. The putative mouse PDE4A10 promoter was amplified from genomic DNA and sub-cloned into a luciferase reporter vector for...

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Identifiers

PMID: 18721873
DOI: 10.1016/j.cellsig.2008.07.017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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