Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cardiomyocyte-Specific Deletion of the Vitamin D Receptor Gene Results in Cardiac Hypertrophy

27 Sept 2011

Abstract excerpt

BACKGROUND: A variety of studies carried out using either human subjects or laboratory animals suggest that vitamin D and its analogues possess important beneficial activity in the cardiovascular system. Using Cre-Lox technology we have selectively deleted the vitamin D receptor (VDR) gene in the cardiac myocyte in an effort to better understand the role of vitamin D in regulating myocyte structure and function....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiac Fibrosis and Remodeling
Share to Signaling Pathways in Disease
Share to Vitamin D Research Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21947295
DOI: 10.1161/circulationaha.111.032680

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cardiomyocyte-Specific Deletion of the Vitamin D Receptor Gene Results in Cardiac HypertrophyPMID 21947295Read ↗

Characterization of heart size and blood pressure in the vitamin D receptor knockout mouse.Semantic proximity Read ↗

Reversibility of adverse, calcineurin-dependent cardiac remodeling.Semantic proximity Read ↗

Heart-specific Deletion of CnB1 Reveals Multiple Mechanisms Whereby Calcineurin Regulates Cardiac Growth and FunctionSemantic proximity Read ↗

Glucocorticoid Receptor ablation promotes cardiac regeneration by hampering cardiomyocyte terminal differentiationSemantic proximity Read ↗

1,25-Dihydroxyvitamin-D3 treatment reduces cardiac hypertrophy and left ventricular diameter in spontaneously hypertensive heart failure-prone (cp/+) rats independent of changes in serum leptin.Semantic proximity Read ↗

1,25-Vitamin D3 promotes cardiac differentiation through modulation of the WNT signaling pathwaySemantic proximity Read ↗

In vitro and in vivo roles of glucocorticoid and vitamin D receptors in the control of neonatal cardiomyocyte proliferative potentialSemantic proximity Read ↗

MEF2 Activates a Genetic Program Promoting Chamber Dilation and Contractile Dysfunction in Calcineurin-Induced Heart FailureSemantic proximity Read ↗

Deletion of the Cardiomyocyte Glucocorticoid Receptor Leads to Sexually Dimorphic Changes in Cardiac Gene Expression and Progression to Heart FailureSemantic proximity Read ↗

Mice with cardiomyocyte-specific disruption of the endothelin-1 gene are resistant to hyperthyroid cardiac hypertrophy.Semantic proximity Read ↗

Novel regulation of cardiac force-frequency relation by CREM (cAMP response element modulator).Semantic proximity Read ↗

Elevated expression of the metabolic regulator receptor-interacting protein 140 results in cardiac hypertrophy and impaired cardiac function.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.