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Article

Atrial natriuretic peptide dose-dependently inhibits pressure overload-induced cardiac remodeling.

Hypertension (Dallas, Tex. : 1979) - 1 Nov 2004

Franco Veronica, Chen Yiu-Fai, Oparil Suzanne, Feng Ji An, Wang Dajun, Hage Fadi, Perry Gilbert

Abstract excerpt

We hypothesized that a single copy of the proatrial natriuretic peptide gene (Nppa+/-) would not be adequate to protect heterozygous mice against exaggerated cardiac hypertrophy and remodeling after pressure-overload stress. Nppa+/+, Nppa+/-, and Nppa-/- mice were subjected to sham surgery or transverse aortic constriction and fed a basal salt diet. Heart weight varied inversely with Nppa gene load by 1 week...

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Source

Identifiers

PMID: 15452027
DOI: 10.1161/01.HYP.0000144801.09557.4c

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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