Article
Age-dependent changes in contractile function and passive elastic properties of myocardium from mice lacking muscle LIM protein (MLP).
European journal of heart failure - 1 Apr 2012
Unsöld Bernhard, Schotola Hanna, Jacobshagen Claudius, Seidler Tim, Sossalla Samuel, Emons Julius, Klede Stefanie, Knöll Ralph, Guan Kaomei, El-Armouche Ali, Linke Wolfgang A, Kögler Harald, Hasenfuss Gerd
Abstract excerpt
AIMS: Muscle LIM protein (MLP) null mice are often used as a model for human dilated cardiomyopathy. So far, little is known about the time course and pathomechanisms leading to the development of the adult phenotype. METHODS AND RESULTS: We systematically analysed the contractile phenotype, myofilament calcium (Ca(2)(+)) responsiveness, passive myocardial mechanics, histology, and mRNA expression in mice aged 4...
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