Article
Preserved cardiac function despite marked impairment of cAMP generation.
PloS one - 1 Jan 2013
Gao Mei Hua, Lai Ngai Chin, Tang Tong, Guo Tracy, Tang Ruoying, Chun Byeong Jo, Wang Hong, Dalton Nancy N, Suarez Jorge, Dillmann Wolfgang H, Hammond H Kirk
Abstract excerpt
OBJECTIVES: So many clinical trials of positive inotropes have failed, that it is now axiomatic that agents that increase cAMP are deleterious to the failing heart. An alternative strategy is to alter myocardial Ca(2+) handling or myofilament response to Ca(2+) using agents that do not affect cAMP. Although left ventricular (LV) function is tightly linked to adenylyl cyclase (AC) activity, the beneficial effects...
Topics
- Adenylyl Cyclases
- Animals
- Calcium
- Calcium Signaling
- Calcium-Binding Proteins
- Cyclic AMP
- Cyclic AMP-Dependent Protein Kinases
- Cyclic Nucleotide Phosphodiesterases, Type 3
- Echocardiography
- Gene Expression