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Article

ABCA1 is essential for efficient basolateral cholesterol efflux during the absorption of dietary cholesterol in chickens.

The Journal of biological chemistry - 11 Apr 2003

Mulligan Jacob D, Flowers Matthew T, Tebon Angie, Bitgood J James, Wellington Cheryl, Hayden Michael R, Attie Alan D

Abstract excerpt

The ATP-binding cassette transporter A1 (ABCA1) participates in the efflux of cholesterol from cells. It remains unclear whether ABCA1 functions to efflux cholesterol across the basolateral or apical membrane of the intestine. We used a chicken model of ABCA1 dysfunction, the Wisconsin hypoalpha mutant (WHAM) chicken, to address this issue. After an oral gavage of radioactive cholesterol, the percentage appearing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12551945
DOI: 10.1074/jbc.M212377200

Genes

ABCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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ABCA1 is essential for efficient basolateral cholesterol efflux during the absorption of dietary cholesterol in chickens.PMID 12551945Read ↗

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