Article
ABCG1 redistributes cell cholesterol to domains removable by high density lipoprotein but not by lipid-depleted apolipoproteins.
The Journal of biological chemistry - 26 Aug 2005
Vaughan Ashley M, Oram John F
Abstract excerpt
ATP binding cassette transporter G1 (ABCG1) mediates the transport of cholesterol from cells to high density lipoprotein (HDL) but not to lipid-depleted apolipoprotein A-I. Here we show that human ABCG1 overexpressed in baby hamster kidney cells in the absence of lipoproteins traffics to the plasma membrane and redistributes membrane cholesterol to cell-surface domains accessible to treatment with the enzyme...
Topics
- ATP Binding Cassette Transporter, Subfamily G, Member 1
- ATP-Binding Cassette Transporters
- Amino Acid Motifs
- Animals
- Apolipoprotein A-I
- Apolipoproteins
- Biological Transport
- Cell Membrane
- Cholesterol
- Cricetinae
- Cross-Linking Reagents
- DNA, Complementary
- Dose-Response Relationship, Drug