Article
Sitosterolemia in ABC-transporter G5-deficient mice is aggravated on activation of the liver-X receptor.
Gastroenterology - 1 Jan 2004
Plösch Torsten, Bloks Vincent W, Terasawa Yuko, Berdy Sara, Siegler Karen, Van Der Sluijs Fjodor, Kema Ido P, Groen Albert K, Shan Bei, Kuipers Folkert, Schwarz Margrit, Schwartz Margrit
Abstract excerpt
BACKGROUND AND AIMS: Mutations in either adenosine triphosphate- binding cassette (ABC) half-transporter G5 or G8 cause sitosterolemia. It has been proposed that ABCG5/ABCG8 heterodimers mediate secretion of plant sterols and cholesterol by hepatocytes into bile and their efflux from enterocytes into the intestinal lumen. METHODS: To test whether deficiency of ABCG5 alone is sufficient to induce sitosterolemia,...
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