Article
The prime role of HDL to transport lutein into the retina: evidence from HDL-deficient WHAM chicks having a mutant ABCA1 transporter.
Investigative ophthalmology & visual science - 1 Sept 2007
Connor William E, Duell P Barton, Kean Ron, Wang Yingming
Abstract excerpt
PURPOSE: Lutein and zeaxanthin are largely transported in plasma by high-density lipoprotein (HDL). The Wisconsin hypoalpha mutant (WHAM) chicken has a recessive sex-linked mutation in the ABCA1 transporter gene that results in a severe deficiency of HDL. In this study, the transport and tissue distribution of lutein and zeaxanthin were examined in newly hatched and 28-day-old WHAM chicks compared with control...
Topics
- ATP Binding Cassette Transporter 1
- ATP-Binding Cassette Transporters
- Animals
- Animals, Genetically Modified
- Animals, Newborn
- Chickens
- Cholesterol, HDL
- Chromatography, High Pressure Liquid
- Diet
- Egg Yolk
- Liver
- Lutein
- Mutation
- Myocardium