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Article

Identification and functional analysis of a naturally occurring E89K mutation in the ABCA1 gene of the WHAM chicken.

Journal of lipid research - 1 Oct 2002

Attie Alan D, Hamon Yannick, Brooks-Wilson Angela R, Gray-Keller Mark P, MacDonald Marcia L E, Rigot Veronique, Tebon Angie, Zhang Lin-Hua, Mulligan Jacob D, Singaraja Roshni R, Bitgood J James, Cook Mark E, Kastelein John J P, Chimini Giovanna, Hayden Michael R

Abstract excerpt

The Wisconsin hypoalpha mutant (WHAM) chicken has a >90% reduction in plasma HDL due to hypercatabolism by the kidney of lipid-poor apoA-I. The WHAM chickens have a recessive white skin phenotype caused by a single-gene mutation that maps to the chicken Z-chromosome. This corresponds to human 9q31.1, a chromosomal segment that contains the ATP-binding cassette protein-1 (ABCA1) gene, which is mutated in Tangier...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12364545
DOI: 10.1194/jlr.m200223-jlr200

Genes

ABCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Identification and functional analysis of a naturally occurring E89K mutation in the ABCA1 gene of the WHAM chicken.PMID 12364545Read ↗

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