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Article

Activity of the bile salt export pump (ABCB11) is critically dependent on canalicular membrane cholesterol content.

The Journal of biological chemistry - 10 Apr 2009

Paulusma Coen C, de Waart D Rudi, Kunne Cindy, Mok Kam S, Elferink Ronald P J Oude

Abstract excerpt

Mutations in ATP8B1 cause severe inherited liver disease. The disease is characterized by impaired biliary bile salt excretion (cholestasis), but the mechanism whereby impaired ATP8B1 function results in cholestasis is poorly understood. ATP8B1 is a type 4 P-type ATPase and is a flippase for phosphatidylserine. Atp8b1-deficient mice display a dramatic increase in the biliary extraction of cholesterol from the...

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Topics

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Share to Adenosine Triphosphatases
Share to ATP Binding Cassette Transporter, Subfamily B, Member 11

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Cholesterol

Share to Multidrug Resistance-Associated Protein 2

Share to Multidrug Resistance-Associated Proteins

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Share to Phospholipid Transfer Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 19228692
DOI: 10.1074/jbc.M808667200
PMCID: PMC2665118

Genes

ABCB11
ABCC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Activity of the bile salt export pump (ABCB11) is critically dependent on canalicular membrane cholesterol content.PMID 19228692Read ↗

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