Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hepatic overexpression of abcb11 promotes hypercholesterolemia and obesity in mice.

Gastroenterology - 1 Oct 2011

Henkel Anne S, Kavesh Mark H, Kriss Michael S, Dewey Amanda M, Rinella Mary E, Green Richard M

Abstract excerpt

BACKGROUND & AIMS: ABCB11 is a canalicular transport protein that controls the rate-limiting step in hepatic bile acid secretion. Its expression levels vary in humans, and it is not clear how these variations affect lipid metabolism. We investigated whether overexpression of Abcb11 in mice increases lipid absorption in the intestine and affects the development of obesity or hypercholesterolemia. METHODS:...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ATP Binding Cassette Transporter, Subfamily B, Member 11
Share to Bile Acids and Salts

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Calorimetry, Indirect

Share to Cholesterol, Dietary

Share to Hypercholesterolemia

Share to Intestinal Absorption

Share to Prealbumin

Share to Weight Gain

Source

Open in PubMed Open full text

Identifiers

PMID: 21726512
DOI: 10.1053/j.gastro.2011.06.062
PMCID: PMC3186850

Genes

TTR
ABCB11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hepatic overexpression of abcb11 promotes hypercholesterolemia and obesity in mice.PMID 21726512Read ↗

Activation of bile acid signaling improves metabolic phenotypes in high-fat diet-induced obese mice.Semantic proximity Read ↗

Hepatic canalicular membrane transport of bile salt in C57L/J and AKR/J mice: implications for cholesterol gallstone formation.Semantic proximity Read ↗

Activity of the bile salt export pump (ABCB11) is critically dependent on canalicular membrane cholesterol content.Semantic proximity Read ↗

Genetic ablation ofCyp8b1preserves host metabolic function by repressing steatohepatitis and altering gut microbiota compositionSemantic proximity Read ↗

Abcb4-defect cholangitis mouse model with hydrophobic bile acid composition by in vivo liver-specific gene deletionSemantic proximity Read ↗

Genetic factors at the enterocyte level account for variations inintestinal cholesterol absorption efficiency among inbred strains of miceSemantic proximity Read ↗

Acceleration of biliary cholesterol secretion restores glycemic control and alleviates hypertriglyceridemia in obese db/db mice.Semantic proximity Read ↗

Both Hepatic and Extrahepatic ABCA1 Have Discrete and Essential Functions in the Maintenance of Plasma High-Density Lipoprotein Cholesterol Levels In VivoSemantic proximity Read ↗

ABCA1 is essential for efficient basolateral cholesterol efflux during the absorption of dietary cholesterol in chickens.Semantic proximity Read ↗

Relative roles of ABCG5/ABCG8 in liver and intestine.Semantic proximity Read ↗

Liver fatty acid binding protein gene ablation potentiates hepatic cholesterol accumulation in cholesterol-fed female mice.Semantic proximity Read ↗

Targeted Deletion of Adipocyte Abca1 (ATP-Binding Cassette Transporter A1) Impairs Diet-Induced Obesity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.