Relative roles of ABCG5/ABCG8 in liver and intestine.

doi:10.1194/jlr.M054544

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Article

Relative roles of ABCG5/ABCG8 in liver and intestine.

Journal of lipid research - 1 Feb 2015

Wang Jin, Mitsche Matthew A, Lütjohann Dieter, Cohen Jonathan C, Xie Xiao-Song, Hobbs Helen H

Abstract excerpt

ABCG5 (G5) and ABCG8 (G8) form a sterol transporter that acts in liver and intestine to prevent accumulation of dietary sterols. Mutations in either G5 or G8 cause sitosterolemia, a recessive disorder characterized by sterol accumulation and premature coronary atherosclerosis. Hepatic G5G8 mediates cholesterol excretion into bile, but the function and relative importance of intestinal G5G8 has not been defined....

Topics

ATP Binding Cassette Transporter, Subfamily G, Member 5
ATP Binding Cassette Transporter, Subfamily G, Member 8
ATP-Binding Cassette Transporters
Animals
Biological Transport
Cholesterol
Enterocytes
Feces
Female
Intestinal Mucosa

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lipoproteins

Liver

Male

Mice

Mice, Knockout

Mutation

Phytosterols

Source

Open in PubMed Open full text

Identifiers

PMID: 25378657
DOI: 10.1194/jlr.M054544
PMCID: PMC4306686

Genes

ABCG5
ABCG8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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