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Article

Zebrafish Abcg2a mutant line as an in vivo model for evaluation of the interaction of Abcg2a with drugs and contaminants.

Aquatic toxicology (Amsterdam, Netherlands) - 1 Feb 2026

Lončar Jovica, Žaja Roko, Mihaljević Ivan, Višević Jelena Dragojević, Vujica Lana, Kutnjak Marin, Otten Cecile, Smital Tvrtko

Abstract excerpt

As a member of the ABC transporter superfamily, ABCG2 is a half transporter that mediates the translocation of various xenobiotic substrates across cell membranes, playing an essential role in cellular detoxification. With the aim of developing a reliable in vivo model to study the role of ABCG2 and its interaction with drugs and environmental contaminants, in this study we used the CRISPR/Cas9 gene-editing...

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Identifiers

PMID: 41534333
DOI: 10.1016/j.aquatox.2026.107709

Genes

ABCG2

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