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Article

MicroRNA expression in Sézary syndrome: identification, function, and diagnostic potential

7 May 2010

Abstract excerpt

MicroRNAs are commonly aberrantly expressed in many cancers. Very little is known of their role in T-cell lymphoma, however. We therefore elucidated the complete miRNome of purified T cells from 21 patients diagnosed with Sézary Syndrome (SzS), a rare aggressive primary cutaneous T-cell (CD4(+)) lymphoma. Unsupervised cluster analysis of microarray data revealed that the microRNA expression profile was distinct...

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PMID: 20448109
DOI: 10.1182/blood-2009-12-256719

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