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Article

DNA methylation maintains allele-specific KIR gene expression in human natural killer cells.

The Journal of experimental medicine - 20 Jan 2003

Chan Huei-Wei, Kurago Zoya B, Stewart C Andrew, Wilson Michael J, Martin Maureen P, Mace Brian E, Carrington Mary, Trowsdale John, Lutz Charles T

Abstract excerpt

Killer immunoglobulin-like receptors (KIR) bind self-major histocompatibility complex class I molecules, allowing natural killer (NK) cells to recognize aberrant cells that have down-regulated class I. NK cells express variable numbers and combinations of highly homologous clonally restricted KIR genes, but uniformly express KIR2DL4. We show that NK clones express both 2DL4 alleles and either one or both alleles...

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Share to Clone Cells
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression

Share to Histocompatibility Antigens Class I

Share to Killer Cells, Natural

Share to Receptors, Immunologic

Share to Receptors, KIR

Share to Receptors, KIR3DL1

Source

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Identifiers

PMID: 12538663
DOI: 10.1084/jem.20021127
PMCID: PMC2193817

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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