Article
A role for DNA hypomethylation and histone acetylation in maintaining allele-specific expression of mouse NKG2A in developing and mature NK cells.
Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 2006
Rogers Sally L, Rouhi Arefeh, Takei Fumio, Mager Dixie L
Abstract excerpt
The repertoire of receptors that is expressed by NK cells is critical for their ability to kill virally infected or transformed cells. However, the molecular mechanisms that determine whether and when NK receptor genes are transcribed during hemopoiesis remain unclear. In this study, we show that hypomethylation of a CpG-rich region in the mouse NKG2A gene is associated with transcription of NKG2A in ex vivo NK...
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