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Article

Epigenetic control of highly homologous killer Ig-like receptor gene alleles.

Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 2005

Chan Huei-Wei, Miller Jeffrey S, Moore Mikel B, Lutz Charles T

Abstract excerpt

Mature human NK lymphocytes express the highly homologous killer Ig-like receptor (KIR) genes in a stochastic fashion, and KIR transcription precisely correlates with allele-specific DNA methylation. In this study, we demonstrate that CpG methylation of a minimal KIR promoter inhibited transcription. In human peripheral blood NK cells and long-term cell lines, expressed KIR genes were associated with a moderate...

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Share to Acetylation
Share to DNA Methylation
Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histones

Share to Promoter Regions, Genetic

Share to Receptors, Immunologic

Share to Receptors, KIR

Share to Transcription, Genetic

Source

Identifiers

PMID: 16237090
DOI: 10.4049/jimmunol.175.9.5966

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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