Article
Genetic and environmental determinants of human NK cell diversity revealed by mass cytometry.
Science translational medicine - 23 Oct 2013
Horowitz Amir, Strauss-Albee Dara M, Leipold Michael, Kubo Jessica, Nemat-Gorgani Neda, Dogan Ozge C, Dekker Cornelia L, Mackey Sally, Maecker Holden, Swan Gary E, Davis Mark M, Norman Paul J, Guethlein Lisbeth A, Desai Manisha, Parham Peter, Blish Catherine A
Abstract excerpt
Natural killer (NK) cells play critical roles in immune defense and reproduction, yet remain the most poorly understood major lymphocyte population. Because their activation is controlled by a variety of combinatorially expressed activating and inhibitory receptors, NK cell diversity and function are closely linked. To provide an unprecedented understanding of NK cell repertoire diversity, we used mass cytometry...
Topics
- Adult
- Cluster Analysis
- Environment
- Female
- Gene Expression Regulation
- Histocompatibility Antigens Class I
- Humans
- Immunologic Memory
- Killer Cells, Natural