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Article

Diversity of NKG2C genotypes in a European population: Conserved and recombinant haplotypes in the coding, promoter, and 3'-untranslated regions.

HLA - 1 Nov 2022

Asenjo Judit, Moraru Manuela, Al-Akioui-Sanz Karima, Altadill Mireia, Muntasell Aura, López-Botet Miguel, Vilches Carlos

Abstract excerpt

NK cells monitor altered molecular patterns in tumors and infected cells through an ample array of receptors. Two families of evolutionarily distant receptors have converged to enable human NK cells to sense levels of HLA class I ligands, frequently abnormal in altered cells. Whilst different forms of polymorphism are a hallmark of killer-cell immunoglobulin-like receptors and their classic HLA-A, B, and C...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35802353
DOI: 10.1111/tan.14734
PMCID: PMC9796621

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