Article
A dynamic mechanism of nuclear receptor activation and its perturbation in a human disease.
Nature structural biology - 1 Feb 2003
Kallenberger Bettina C, Love James D, Chatterjee V Krishna K, Schwabe John W R
Abstract excerpt
Nuclear receptors are transcription factors that activate gene expression in response to ligands. The C-terminal helix (helix 12) of the ligand-binding domain plays a critical role in the activation mechanism. When bound to activating ligands, helix 12 adopts a conformation that promotes the binding of co-activator proteins. Helix 12 also adopts this 'active' position in several ligand-free structures, raising...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.