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Article

Helix 12 stabilization contributes to basal transcriptional activity of PXR.

The Journal of biological chemistry - 1 Sept 2021

Shizu Ryota, Nishiguchi Hikaru, Tashiro Sarii, Sato Takumi, Sugawara Ayaka, Kanno Yuichiro, Hosaka Takuomi, Sasaki Takamitsu, Yoshinari Kouichi

Abstract excerpt

Pregnane X receptor (PXR) plays an important role in xenobiotic metabolism. While ligand binding induces PXR-dependent gene transcription, PXR shows constitutive transcriptional activity in the absence of ligands when expressed in cultured cells. This constitutive activity sometimes hampers investigation of PXR activation by compounds of interest. In this study, we investigated the molecular mechanism of PXR...

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Identifiers

PMID: 34284062
DOI: 10.1016/j.jbc.2021.100978
PMCID: PMC8390552

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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