Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Crystal structure of the HNF4 alpha ligand binding domain in complex with endogenous fatty acid ligand.

The Journal of biological chemistry - 11 Oct 2002

Dhe-Paganon Sirano, Duda Karen, Iwamoto Melanie, Chi Young-In, Shoelson Steven E

Abstract excerpt

HNF4 alpha is an orphan member of the nuclear receptor family with prominent functions in liver, gut, kidney and pancreatic beta cells. We have solved the x-ray crystal structure of the HNF4 alpha ligand binding domain, which adopts a canonical fold. Two conformational states are present within each homodimer: an open form with alpha helix 12 (alpha 12) extended and collinear with alpha 10 and a closed form with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
Share to Crystallography, X-Ray

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dimerization

Share to Fatty Acids

Share to Hepatocyte Nuclear Factor 4

Share to Ligands

Share to Phosphoproteins

Share to Receptors, Cytoplasmic and Nuclear

Source

Identifiers

PMID: 12193589
DOI: 10.1074/jbc.C200420200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Crystal structure of the HNF4 alpha ligand binding domain in complex with endogenous fatty acid ligand.PMID 12193589Read ↗

Structural insights into the HNF4 biologySemantic proximity Read ↗

Multidomain integration in the structure of the HNF-4α nuclear receptor complex.Semantic proximity Read ↗

Critical role of residues defining the ligand binding pocket in hepatocyte nuclear factor-4alpha.Semantic proximity Read ↗

Molecular mechanism of HNF-1A–mediated HNF4A gene regulation and promoter-driven HNF4A-MODY diabetesSemantic proximity Read ↗

Structural and biophysical characterization of HNF-1A as a tool to study MODY3 diabetes variantsSemantic proximity Read ↗

Crystallographic identification and functional characterization of phospholipids as ligands for the orphan nuclear receptor steroidogenic factor-1.Semantic proximity Read ↗

Structural and biophysical characterization of transcription factor HNF-1A as a tool to study MODY3 diabetes variants.Semantic proximity Read ↗

Role of regulatory F-domain in hepatocyte nuclear factor-4alpha ligand specificity.Semantic proximity Read ↗

Role of HNF6 in liver homeostasis and pathophysiologySemantic proximity Read ↗

Structural properties of the HNF-1A transactivation domainSemantic proximity Read ↗

Structural properties of the HNF-1A transactivation domainSemantic proximity Read ↗

Structural basis of dimerization, coactivator recognition and MODY3 mutations in HNF-1alpha.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.