Article

Impaired transitioning of the FXR ligand binding domain to an active state underlies an FXR-associated PFIC phenotype

2024-02-12

Abstract excerpt

Nuclear receptor farnesoid X receptor (FXR) acts as a key regulator of bile acid pool homeostasis and metabolism. Within the enterohepatic circulation, reabsorbed bile acids act as FXR agonists, which transcriptionally controls the synthesis and transport of bile acids. Binding occurs in the ligand binding domain (LBD), favoring a conformational change to the active state in which helix 12 interacts with the LBD t...

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Literature Corpus work: d93f6394-6d27-5812-97d8-a4ca6a1d085f
DOI: 10.1101/2024.02.08.579530

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