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Article

Structural determinants of the agonist-independent association of human peroxisome proliferator-activated receptors with coactivators.

The Journal of biological chemistry - 15 Jul 2005

Molnár Ferdinand, Matilainen Merja, Carlberg Carsten

Abstract excerpt

Lipid homeostasis is controlled by various nuclear receptors (NRs), including the peroxisome proliferator-activated receptors (PPARalpha, delta, and gamma), which sense lipid levels and regulate their metabolism. Here we demonstrate that human PPARs have a high basal activity and show ligand-independent coactivator (CoA) association comparable with the NR constitutive androstane receptor. Using PPARgamma as an...

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PMID: 15888456
DOI: 10.1074/jbc.M502463200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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