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Article

Helix 1/8 interactions influence the activity of nuclear receptor ligand-binding domains.

Molecular endocrinology (Baltimore, Md.) - 1 Sept 2003

Holt Jason A, Consler Thomas G, Williams Shawn P, Ayscue Andrea H, Leesnitzer Lisa M, Wisely G Bruce, Billin Andrew N

Abstract excerpt

The ligand-binding domain (LBD) of apo-nuclear receptors in solution is thought to be a very dynamic structure with many possible conformations. Upon ligand binding, the structure is stabilized to a more rigid conformation. The dynamic stabilization assay is a LBD reassembly assay that takes adva...

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Identifiers

PMID: 12817079
DOI: 10.1210/me.2003-0001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12817079-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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