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Article

A molecular switch regulating transcriptional repression and activation of PPARγ.

Nature communications - 19 Feb 2020

Shang Jinsai, Mosure Sarah A, Zheng Jie, Brust Richard, Bass Jared, Nichols Ashley, Solt Laura A, Griffin Patrick R, Kojetin Douglas J

Abstract excerpt

Nuclear receptor (NR) transcription factors use a conserved activation function-2 (AF-2) helix 12 mechanism for agonist-induced coactivator interaction and NR transcriptional activation. In contrast, ligand-induced corepressor-dependent NR repression appears to occur through structurally diverse mechanisms. We report two crystal structures of peroxisome proliferator-activated receptor gamma (PPARγ) in an inverse...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32075969
DOI: 10.1038/s41467-020-14750-x
PMCID: PMC7031403

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