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Article

Relationship between E-cadherin gene mutation and p53 gene mutation, p53 accumulation, Bcl-2 expression and Ki-67 staining in diffuse-type gastric carcinoma.

International journal of cancer - 10 Mar 2003

Fricke Elena, Keller Gisela, Becker Ingrid, Rosivatz Erika, Schott Christina, Plaschke Susanne, Rudelius Martina, Hermannstädter Christine, Busch Raymonde, Höfler Heinz, Becker Karl-Friedrich, Luber Birgit

Abstract excerpt

E-cadherin mutations are found in 50% of diffuse-type gastric carcinoma, but not in intestinal gastric carcinoma. Because cell-cell adhesion mediated by E-cadherin plays an important role in epithelial cell survival, E-cadherin mutations could alter the apoptotic behavior of tumor cells. p53 and Bcl-2 family members are also important regulators of cellular apoptosis. This is the first study that investigates the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 12532420
DOI: 10.1002/ijc.10879

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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