Article
Distribution of p53 mutations in esophageal and gastric carcinomas and the relationship with p53 expression.
Oncology reports - 1 Apr 2006
Hanazono Koichi, Natsugoe Shoji, Stein Hubert J, Aikou Takashi, Hoefler Heinz, Siewert J Ruediger
Abstract excerpt
Mutations of p53, a tumor suppressor gene, are known to be involved in the pathogenesis of a number of neoplasms. This study investigated the distribution of p53 mutations within both esophageal and gastric adenocarcinomas. The correlation between p53 mutations and an overexpression of p53, which has been reported by other researchers, was also explored. Samples were taken from 17 patients following a surgical...
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