Article
Overexpression of p53 predicts shorter survival in diffuse type gastric cancer.
The British journal of surgery - 1 Aug 1998
Lee W J, Shun C T, Hong R L, Wu M S, Chang K J, Chen K M
Abstract excerpt
BACKGROUND: It has been suggested that p53 plays an important part in gastric carcinogenesis but the data remain inconclusive. METHODS: Alteration of the tumour suppressor gene p53 was prospectively investigated by immunohistochemistry in 168 primary gastric cancers. RESULTS: Positive staining, indicative of gene mutations, was detected in 34 tumours (20.2 per cent). No correlation was observed between expression...
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