Article
[Diffuse stomach carcinoma: from H&E diagnosis and molecular pathology to specific therapy].
Verhandlungen der Deutschen Gesellschaft fur Pathologie - 1 Jan 1999
Höfler H
Abstract excerpt
E-cadherin is a homophilic cell adhesion molecule that is mutated in half of diffuse-type gastric cancer patients. Since these mutations generally affect the extracellular portion of the transmembrane molecule and do not interrupt the reading frame, altered E-cadherin protein may be an excellent tumor marker. We established a rapid PCR-based E-cadherin mutation detection technique allowing positive results within...
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